Poul astrup biography

  • Poul Bjørndahl Astrup (4 August 1915 – 30 November 2000) was a Danish clinical chemist famous for inventing a CO2 electrode and co-inventing the concept of.
  • Poul Bjørndahl Astrup was a Danish clinical chemist famous for inventing a CO₂ electrode and co-inventing the concept of base excess.
  • Danish physiological chemist, born 1915.

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    Career perspective: John W. Severinghaus

    • Career perspective
    • Open access
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    Extreme Physiology & Medicinevolume 2, Article number: 29 (2013) Cite this article

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    Abstract

    After training in physics during World War II, I spent 2 years designing radar at Massachusetts Institute of Technology and then switched to biophysics. After medical school and a residency, I was doctor drafted to National Institutes of Health where I studied blood gas transport in hypothermia and developed the carbon dioxide electrode and the blood gas analyzer (pH, partial pressure of O2, and partial pressure of CO2). I joined the University of California San Francisco in 1958 in a new anesthesia department and new Cardiovascular Research Institute. My research aims were anesthesia patient monitoring, respiratory physiology, blood gas transport, and high-altitude acclimatization and pathology.

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    I arrived foot-first unde

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    History of blood gas analysis. inom. The development of electrochemistry

    In 1982 Poul Astrup, in writing a history of acid base balance and blood gases, invited me to contribute a chapter about the modern period, from 1950 to the present. Astrup's book fryst vatten scheduled for publication at the end of 1985 by Radiometer Company of Copenhagen; it will be distributed bygd Munksgaard (Blackwell). The story of blood gas analysis since 1950 is vast: there are some 420 references to methodology and closely related physiology. This "modern" history will appear in the Journal of Clinical Monitoring as a series of essays. This first essay centers on electrochemistry, the basis of modern blood gas analysis, and accordingly examines its roots in more detail. The 17th and 18th century utforskning of electricity and gas laws led to the development of thermodynamic electrochemistry in 1887 through the collaborative efforts of van't Hoff, Arrhenius, Ostwald, and Nernst. The importance of the hydrogen ion

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    Siggaard-Andersen and the "Great Trans-Atlantic Acid-Base Debate"

    In the late 1950's, while working with Poul Astrup's equilibration method of blood gas analysis, Siggaard-Andersen introduced a new parameter called base excess (BE) to quantify the non-respiratory acid-base imbalance. "The Great-Transatlantic Acid-Base Debate" arose when the "Boston" school, whose bicarbonate based analysis had been developed during pre-1950 Van Slyke days, (initially) argued that BE was not independent of PCO2 in vivo. Although Siggaard-Andersen and others then introduced a standard BE independent of PCO2, the Boston and Copenhagen schools are "unreconciled". While SBE is now used by most physicians, teaching and interpretation of acid-base chemistry remains confusing, "Boston" school laboratories refusing to report SBE, their students being asked to learn the 6 bicarbonate equations and rules, an old concept being reintroduced as "strong ion difference", or SID, and some wanting to di

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